The Calmare® device is an FDA-cleared and CE-certified medical device offering non-invasive treatment for chronic neuropathic and oncologic pain. Using surface electrodes, it delivers a “no-pain” signal designed to override pain signals to the brain. Calmare means “to soothe or ease” in Italian—an apt description for a treatment designed to provide relief without the side effects and addictive properties associated with narcotic painkillers.
Calmare Scrambler Therapy is available at 465 Park 40 N Blvd, Knoxville, TN 37923.
During treatment, surface electrodes are applied to the skin. The Calmare device uses a biophysical approach to transmit a “no-pain” message, replacing the pain signal and helping cancel the perception of pain. Relief may be immediate regardless of pain intensity, while maximum benefit is typically achieved through follow-up treatments based on the underlying cause and severity of pain.

Calmare treatment is non-invasive and painless, with the potential for immediate pain relief and ongoing pain control. It is intended to offer an option without the adverse side effects of opioids and other drugs.
The platform features five independent channels, disposable surface electrodes, independent output intensity on each channel, a dynamic synthesizer processor, and a maximum output current of 5mA RMS.
The Calmare® platform is designed for people living with chronic pain, particularly neuropathic and oncologic pain. Knox Physical Therapy notes that clinical studies have shown more than 80% of treated patients experience significant pain reduction and improved quality of life.
Calmare has been used as a biophysical pain-management approach for chemotherapy-induced peripheral neuropathy (CIPN).
Individuals experiencing phantom limb syndrome may be candidates for this non-invasive, electrode-based therapy.
The Calmare approach has also been used for sciatica, post-surgical neuropathic pain, and other chronic pain presentations.
If chronic neuropathic or oncologic pain is affecting your quality of life, contact Knox Physical Therapy to learn more about Calmare Scrambler treatment. Our Cedar Bluff team can help you take the next step toward a treatment plan tailored to your needs.